Objectives: To study the consent process experienced by participants who are enrolled in a molecular genetic research study that aims to find new genetic mutations responsible for an apparently inherited disorder.Design: Semi-structured interviews and analysis/description of main themes.Participants: 78 members of 52 families who had been recruited to a molecular genetic study.Results: People were well informed about the goals, risks and benefits of the genetic research study but could not remember the consent process. They had mostly been recruited to take (...) part by trusted clinicians or their relatives but had little memory of, or concern about signing consent forms. Families appeared to regard the research as a continuation of their, or their relatives’, clinical care.Conclusions: Ethical review should be more flexible in its attitude to consent forms and written information sheets for some sorts of research. For rare genetic disease studies where research has been discussed fully within the clinical setting then the consent obtained at that time could suffice rather than needing extra consent at a later stage. However, clinician-researchers will need to ensure that their duty of care extends for the duration of the research and beyond. (shrink)

Presents a plethora of approaches to developing human potential in areas not conventionally addressed. Organized in two parts, this international collection of essays provides viable educational alternatives to those currently holding sway in an era of high-stakes accountability.

Teachers in inclusive schools are often faced with the challenge of providing appropriate educational experiences for classes of students with abilities ranging from gifted to severely learning disabled. This challenge can be addressed either by the individual teacher or by a whole school approach. This paper reports on a study of the responses of teachers and parents to a trial of 'cluster grouping', as a model for meeting the educational needs of exceptional students. Data were gathered from teachers and parents (...) by questionnaire. The results remind us that there are factors, other than the strengths and weaknesses of a particular model, that can influence success. (shrink)

This book details Harris’s travels throughout the globe among common people through sixty-seven countries over twelve years. She stayed in a harem, wore a burqa, and slept on a sidewalk through the biggest battle in the Algerian War! Questions evoke critical reading and philosophical thought, and the book includes a bibliography of suggestions for further reading.

Conducting research with vulnerable populations involves careful attention to the interests of individuals. Although it is generally understood that informed consent is a necessary prerequisite to research participation, it is less clear how to proceed when potential research participants lack the capacity to provide this informed consent. The rationale for assessing the assent or dissent of vulnerable individuals and obtaining informed consent by authorized representatives is discussed. Practical guidelines for recruitment of and data collection from people in the middle or (...) late stage of dementia are proposed. These guidelines were used by research assistants in a minimal risk study. (shrink)

The aim of this paper is to determine whether and to what extent Woodward’s interventionist theory of causation is variable relative. In an influential review, Strevens has accused Woodward’s account of a damaging form of variable relativity, according to which obviously false causal claims can be made true by choosing a depleted variable set. Following McCain, I show that Strevens’ objection doesn’t succeed. However, Woodward also wants to avoid another kind of variable relativity, according to which it can be true (...) that X is a cause of Y in one set of background conditions, but false in another. I show that Woodward’s account is problematically overpermissive, unless there are restrictions on the values that certain variables can take. I formulate a modified account that makes these restrictions explicit, then use it to argue that Woodward’s attempt to avoid relativity to background conditions is misguided. On the best interpretation of the interventionist theory, causal claims are assessed relative to a particular kind of variable set. Thus, I conclude that the theory should be understood as variable relative, in a specific, unproblematic sense. (shrink)

These past few days, I have been reading a transcript of your speech at the Military Academy on 18 September [1966] and, to be frank, some of the key formulations in it are highly erroneous.

I apply James Woodward’s interventionist theory of causation to organic chemistry, modelling three different ways that chemists are able to manipulate the reaction conditions in order to control the outcome of a reaction. These consist in manipulations to the reaction kinetics, thermodynamics, and whether the kinetics or thermodynamics predominates. It is possible to construct interventionist causal models of all of these kinds of manipulation, and therefore to account for them using Woodward’s theory. However, I show that there is an alternate, (...) more illuminating way of thinking about the third kind of reaction control, according to which chemists are thought of as manipulating which causal system is instantiated. I show that our ability to manipulate which system is instantiated is an important part of our ability to control the world, as is therefore especially relevant to interventionism. Thus, considering examples from organic chemistry leads to the identification of an important extension to Woodward’s theory. Finally, this investigation into reaction control in organic chemistry also has a more general implication: it suggests that interventionism results in a version of pragmatism about causation. (shrink)

Recently, there has been a large amount of support for the idea that causal claims can be sensitive to normative considerations. Previous work has focused on the concept of actual causation, defending the claim that whether or not some token event c is a cause of another token event e is influenced by both statistical and prescriptive norms. I focus on the policy debate surrounding alternative energies, and use the causal modelling framework to show that in this context, people’s normative (...) commitments don’t just affect the causal claims they are willing to endorse, but also their understanding of the causal structure. In the context of the alternative energy debate, normative considerations affect our understanding of the causal structure by influencing our judgements about which variables should be held fixed, and therefore which variables should be relegated to the background of a causal model. In cases of extreme disagreement, normative commitments can also affect which causal structure we think should be instantiated. Thus, focusing on a new context has revealed a previously unexplored sense in which normative factors are incorporated into causal reasoning. (shrink)

This paper provides a starting point for thinking beyond a research–practice divide and discusses possible new conceptualizations of intervention and the role of IT research in contemporary organizational settings. ‘IT research’ denotes a conglomerate of overlapping research conducted under the headings of Information Systems, Systems Development, Critical IS Research and Participatory Design. The paper applies this joint notion of IT research and the IT researcher to draw parallels across these niches of research regarding the question of intervention. Through an analysis (...) of selected field study events, a prominent notion of intervention (as being active as opposed to being passive) is reworked in terms of intervention as circumstance, a circumstantial interplay of situated practices. In closing, subsequent possibilities for repositioning the IT researcher are discussed in terms of reflexivity, facilitation or being a trickster. (shrink)

Recent studies indicate that mammalian chromosomes contain discretecis‐acting loci that control replication timing, mitotic condensation, and stability of entire chromosomes. Disruption of the large non‐coding RNA gene ASAR6 results in late replication, an under‐condensed appearance during mitosis, and structural instability of human chromosome 6. Similarly, disruption of the mouse Xist gene in adult somatic cells results in a late replication and instability phenotype on the X chromosome. ASAR6 shares many characteristics with Xist, including random mono‐allelic expression and asynchronous replication timing. (...) Additional “chromosome engineering” studies indicate that certain chromosome rearrangements affecting many different chromosomes display this abnormal replication and instability phenotype. These observations suggest that all mammalian chromosomes contain “inactivation/stability centers” that control proper replication, condensation, and stability of individual chromosomes. Therefore, mammalian chromosomes contain four types ofcis‐acting elements, origins, telomeres, centromeres, and “inactivation/stability centers”, all functioning to ensure proper replication, condensation, segregation, and stability of individual chromosomes. (shrink)

ABSTRACT Contrastive and deviant/default accounts of causation are becoming increasingly common. However, discussions of these accounts have neglected important questions, including how the context determines the contrasts, and what shared knowledge is necessary for this to be possible. I address these questions, using organic chemistry as a case study. Focusing on one example—nucleophilic substitution—I show that the kinds of causal claims that can be made about an organic reaction depend on how the reaction is modelled, and argue that paying attention (...) to the various ways that reactions are modelled has important implications for our understanding of causation. _1_ Introduction _2_ General Contrastive Causal Claims in Organic Chemistry _3_ Deviant Causal Claims in Organic Chemistry _4_ Nucleophilic Substitution Reactions _5_ The Causal Modelling Tradition _5.1_ The type/token distinction _6_ Competing Reactions _6.1_ Type- and token-causal claims, variables, and values of variables _7_ Disambiguation of ‘Reaction’ _8_ Reaction Kinds _9_ Specific Reactions _9.1_ Specific reactions and token-causal claims _9.2_ Specific reactions and type-causal claims _10_ Implications _10.1_ Kinds of causal claim _10.2_ Contrastive and deviant causal claims _10.3_ Model relativity. (shrink)

The research literature on parenting support typically focuses on English-speaking countries, such as England, the United States and Australia. This article draws on a review, commissioned by the English government, which examined policies and services to support parenting in five European countries: Denmark, France, Germany, Italy and the Netherlands, and considered the evidence for effectiveness. In exploring differences between the five countries, and with England, this article raises questions about the way in which understandings of ?what works? can inform the (...) ways in which support for parents and families is designed and delivered. An emphasis on formal outcome evaluations, as in England, favours the use of standardised parenting programmes, which are more amenable to evaluation of effectiveness using quasi-experimental research designs. In some other European countries, support for parents and families is embedded in universal service provision, rather than a discrete, time-limited ?intervention?, and hence evaluation is more likely to involve assessment of individual progress (is this working for this family?) rather than assessment of the overall efficiency of a standardised programme. (shrink)

The crisis of western civilization is a crisis of public philosophy. This is the charge of Public Philosophy and Political Science, a stunning new collection of essays edited by E. Robert Statham Jr. Vividly cataloging the decay of the moral and intellectual foundations of civic liberty, the book portrays a generation of Americans alienated from institutions built on public philosophy. The work exposes the failure of America's political scientists to acknowledge and understand this alarming crisis in the American body (...) politic. The distinguished contributors examine the evolution of public philosophy; the inextricable relationship between politics and philosophy; and the interplay between public philosophy, the constitution, natural law, and government. They reveal the dire threat to deliberative democracy and the fundamental order of constitutional society posed by public philosophy's waning power to refine, cultivate, and civilize. The work is an indictment of a society which has discarded a way of life rooted in natural law, democracy and the traditions of civility; and is a denunciation of an educated elite that has divorced itself from the standards upon which public philosophy rests. It is essential reading for philosophers and political and social scientists seeking to resurrect the standards of American public life. (shrink)

America, and the postmodern West in particular, are experiencing a moral and intellectual crisis, according to E. Robert Statham, Jr. In The Constitution of Public Philosophy, Statham argues that Walter Lippman was correct in locating this crisis in the impoverished nature of public philosophy, and he attempts to constitute a role for reason in contemporary America. Statham suggests that the negative rule of law via a written constitution requires the positive rule of reason, or political philosophy, in (...) order to flourish. (shrink)

A historical investigation of the exclusion of Africa and Asia from modern histories of philosophy.

In the area of social science, in particular, although we have developed methods for reliably discovering the existence of causal relationships, we are not very good at using these to design effective social policy. Cartwright argues that in order to improve our ability to use causal relationships, it is essential to develop a theory of causation that makes explicit the connections between the nature of causation, our best methods for discovering causal relationships, and the uses to which these are put. (...) I argue that Woodward’s interventionist theory of causation is uniquely suited to meet Cartwright’s challenge. More specifically, interventionist mechanisms can provide the bridge from ‘hunting causes’ to ‘using them’, if interventionists (i) tell us more about the nature of these mechanisms, and (ii) endorse the claim that it is these mechanisms (or whatever constitutes them) that make causal claims true. I illustrate how having an understanding of interventionist mechanisms can allow us to put causal knowledge to use via a detailed example from organic chemistry. (shrink)

Vaesen infers unique properties of mind from the appearance of specific cultural innovation – a correlation without causal direction. Shifts in habitat, population density, and group dynamics are the only independently verifiable incentives for changes in cultural practices. The transition from Acheulean to Late Stone Age technologies requires that we consider how population and social dynamics affect cultural innovation and mental function.

The first English translation of Fichte’s second set of 1804 lectures on the Wissenschaftslehre.

Orthologic is defined by weakening the axioms and rules of inference of the classical propositional calculus. The resulting Lindenbaum-Tarski quotient algebra is an orthoimplication algebra which generalizes the author's implication algebra. The associated order structure is a semi-orthomodular lattice. The theory of orthomodular lattices is obtained by adjoining a falsity symbol to the underlying orthologic or a least element to the orthoimplication algebra.

Providing an original and systematic treatment of foundational issues in philosophy of religion, J. L. Schellenberg's new book addresses the structure of..

Objective To study parental attitudes to participating in questionnaire research about perinatal postmortem immediately after late miscarriage, stillbirth and termination for fetal abnormality. Design Prospective self-completion questionnaire. Setting UK fetal medicine and delivery unit. Patients 35 women and their partners after second or third trimester pregnancy loss, making decisions about having a postmortem. Methods Participants were asked to complete a questionnaire about postmortem decision-making which included questions about their attitudes to taking part in research. Prior to giving full approval for (...) the study, the Research Ethics Committee requested feedback after 10 questionnaires had been returned. Results Responses from the first 10 participants were positive about the research and the REC allowed the study to continue. 31 questionnaires were received from parents of 17 babies. Of the 22 participants who answered a question about the impact of participating in this research, 73% stated that completing the questionnaire had helped them feel better about the decision whether or not to consent to postmortem and none reported any adverse effect of completing the questionnaire. Additional comments made by 19 participants supported this finding. Conclusion Research into this sensitive area of perinatal medicine where there is a poor outcome is possible and is indeed well received by many parents. RECs should not automatically take a negative stance towards studies of this type. (shrink)

According to realist structuralism, mathematical objects are places in abstract structures. We argue that in spite of its many attractions, realist structuralism must be rejected. For, first, mathematical structures typically contain intra-structurally indiscernible places. Second, any account of place-identity available to the realist structuralist entails that intra-structurally indiscernible places are identical. Since for her mathematical singular terms denote places in structures, she would have to say, for example, that 1 = − 1 in the group (Z, +). We call this (...) the identity problem and conclude that nominalism is presently the safest route for the structuralist. (shrink)

This paper takes the form of a ‘performative’ dialogue, a recounting of scenes, which alternate, in the mode of a cinematic montage, with academic analysis of the interfaces between boxing, art, and space. In his book Body and Soul: Notebooks on an Apprentice Boxer, sociologist Loïc Wacquant mixes three genres: analytic sociology, depictive ethnography, and short story. He argues that he used this unorthodox methodology ‘to make the reader simultaneously feel and understand how boxers are “gripped” by their craft and (...) viscerally tied to it’. Similarly, in this paper, the overlapping voices of its two authors engage in both performative, creative and intellectual ways with the critiques and social rituals surrounding boxing, ultimately finding that an understanding of boxing as an epistemological encounter gives rise to interesting ways to think through the relationships between art and urban space itself. The paper ranges widely over each author’s personal experience of boxing, analyses of specific artworks both ancient and modern, and an analysis of the psychogeography of urban space, and in particular, Johannesburg. The form of the paper, as it incorporates narrative experience and analytic mode, can be seen as a text that re-enacts the ‘performance’ of boxing and art-making in which the traditional opposition between the two is integrated, if not suspended. (shrink)

Ned Block argues that the higher-order (HO) approach to explaining consciousness is ‘defunct’ because a prominent objection (the ‘misrepresentation objection’) exposes the view as ‘incoherent’. What’s more, a response to this objection that I’ve offered elsewhere (Weisberg 2010) fails because it ‘amounts to abusing the notion of what-it’s-like-ness’ (xxx).1 In this response, I wish to plead guilty as charged. Indeed, I will continue herein to abuse Block’s notion of what-it’s-like-ness. After doing so, I will argue that the HO approach accounts (...) for the sense of what-it’s-like-ness that matters in a theory of consciousness. I will also argue that the only incoherence present in the HO theory is that generated by embracing Block’s controversial notion of what-it’s-like-ness, something no theorist of any stripe ought to do. Block is famous for (among other things) having introduced the notion of ‘phenomenal consciousness’ into contemporary philosophy of mind (Block 1995). This term is widely employed in the philosophical literature and it even appears in the empirical literature. But wide-speared usage has brought about divergent interpretations of the term. We can distinguish a ‘moderate’ and a ‘zealous’ reading of ‘phenomenal consciousness’. On the moderate reading, ‘phenomenal consciousness’ just means ‘experience’. Many people have embraced this sense of the term and use it to roughly pick out conscious experience involving sensory quality (states like conscious visual experiences or conscious pains, for example).2 On the zealous reading, however, phenomenal consciousness is held to be ‘distinct from any cognitive, intentional, or functional property’ (Block 1995: 234). That is, any explanation of phenomenal consciousness in exclusively cognitive, intentional, or functional terms will fail to capture, without remainder, what is really distinctive about phenomenal consciousness. Block, of course, is fully clear about embracing the zealous reading; indeed, his initial introduction of the notion is in those terms. The same ambiguity occurs with the much-used (and abused) idea of ‘what-it’s-like-ness’.. (shrink)

Scientists and laypeople alike use the sense of understanding that an explanation conveys as a cue to good or correct explanation. Although the occurrence of this sense or feeling of understanding is neither necessary nor sufficient for good explanation, it does drive judgments of the plausibility and, ultimately, the acceptability, of an explanation. This paper presents evidence that the sense of understanding is in part the routine consequence of two well-documented biases in cognitive psychology: overconfidence and hindsight. In light of (...) the prevalence of counterfeit understanding in the history of science, I argue that many forms of cognitive achievement do not involve a sense of understanding, and that only the truth or accuracy of an explanation make the sense of understanding a valid cue to genuine understanding. (shrink)